基本介绍
朱冠恒
博士 副教授 硕导
Email: zhugh8@mail.sysu.edu.cn
专业方向
农业昆虫与害虫防治（植物保护）
研究方向：昆虫生理与分子生物学。
主攻方向：一、昆虫生长发育的激素与基因调节；二、精准基因编辑及转基因技术在非模式昆虫的应用和拓展。
人才项目
百人计划
教育经历
2012.09-2017.06，南京农业大学，农业昆虫与害虫防治，博士
2008.09-2012.06，河南农业大学，植物保护，学士
工作经历
2024.04至今，中山大学，农业与生物技术学院，副教授
2021.01-2024.03，中山大学，农学院，副教授
2017.09-2020.12，肯塔基大学，博士后
科研成果（#同等贡献，*通讯作者）
2024
Fan, S.-T., Zheng, Z.-J., Feng, Q., and Zhu, G.-H.* （2024）Azadirachtin induces fat body apoptosis by suppressing Caspase-8 in the fall armyworm, Spodoptera frugiperda. Journal of Agricultural and Food Chemistry 72, 1932-19332.
Koo, J., Zhu, G.-H., and Palli, S.R.* (2024). CRISPR-Cas9 mediated dsRNase knockout improves RNAi efficiency in the fall armyworm. Pesticide Biochemistry and Physiology, 105839.
2023
Jiao, Y., Zhu, G.-H., Chen, X., Dhandapani, R.K., and Palli, S.R. * (2023). The function of mitochondrial regulator LRPPRC in Aedes aegypti and its potential for mosquito control. Journal of Pest Science, 1-13.
Fan, S.-T., Wu, M.-Z., Liu, C., Li, H.-H., Huang, S.-H., Zheng, Z.-J., Ye, X.-Y., Tan, J.-F., and Zhu, G.-H. * (2023). Azadirachtin inhibits nuclear receptor HR3 in the prothoracic gland to block larval ecdysis in the fall armyworm, Spodoptera frugiperda. Journal of Agricultural and Food Chemistry 71, 15497-15505.
2022
Zhu, G.-H., Gaddelapati, S.C., Jiao, Y., Koo, J., and Palli, S.R. * (2022). CRISPR-Cas9 genome editing uncovers the mode of action of methoprene in the yellow fever mosquito, Aedes aegypti. The CRISPR Journal 5, 813-824.
Luo, G.-H., Chen, X.-E., Jiao, Y.-Y., Zhu, G.-H., Zhang, R., Dhandapani, R.K., Fang, J.-C., and Palli, S.R. * (2022). SoxC is required for ecdysteroid induction of neuropeptide genes during insect eclosion. Frontiers in Genetics 13, 942884.
2021
Zhu, G.-H., Albishi, N.M., Chen, X., Brown, R.L., and Palli, S.R. * (2021). Expanding the Toolkit for genome editing in a disease vector, Aedes aegypti: transgenic lines expressing Cas9 and single guide RNA induce efficient mutagenesis. The CRISPR Journal 4, 846-853.
Wang, K., Cheng, H., Chen, J., Zhu, G.-H., Tang, P., and Han, Z. * (2021). Chimeric double-stranded RNAs could act as tailor-made pesticides for controlling storage insects. Journal of Agricultural and Food Chemistry 69, 6166-6171.
Peng, Y., Zhu, G.-H. *, Wang, K., Chen, J., Liu, X., Wu, M., Zhao, C., Xiao, H., Palli, S.R., and Han, Z. * (2021). Knockout of SldsRNase1 and SldsRNase2 revealed their function in dsRNA degradation and contribution to RNAi efficiency in the tobacco cutworm, Spodoptera litura. Journal of Pest Science 94, 1449-1460.
Chen, J., Peng, Y., Zhang, H., Wang, K., Zhao, C., Zhu, G.-H., Reddy Palli, S., and Han, Z. * (2021). Off-target effects of RNAi correlate with the mismatch rate between dsRNA and non-target mRNA. RNA biology 18, 1747-1759.
Chen, J., Peng, Y., Zhang, H., Wang, K., Tang, Y., Gao, J., Zhao, C., Zhu, G.-H., Palli, S.R., and Han, Z. * (2021). Transcript level is a key factor affecting RNAi efficiency. Pesticide Biochemistry and Physiology 176, 104872.
2020
Zhu, G.-H., Chereddy, S.C., Howell, J.L., and Palli, S.R. * (2020). Genome editing in the fall armyworm, Spodoptera frugiperda: Multiple sgRNA/Cas9 method for identification of knockouts in one generation. Insect Biochemistry Molecular Biology 122, 103373.
Xu, J., Liu, W., Yang, D., Chen, S., Chen, K., Liu, Z., Yang, X., Meng, J., Zhu, G.-H., Dong, S., Wang G. and Huang Y. * (2020). Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade. PLoS Genetics 16, e1008622.
Peng, Y., Wang, K., Zhu, G.-H., Han, Q., Chen, J., Elzaki, M.E.A., Sheng, C., Zhao, C., Palli, S.R., and Han, Z. * (2020). Identification and characterization of multiple dsRNases from a lepidopteran insect, the tobacco cutworm, Spodoptera litura (Lepidoptera: Noctuidae). Pesticide Biochemistry and Physiology 162, 86-95.
Peng, Y., Wang, K., Chen, J., Wang, J., Zhang, H., Ze, L., Zhu, G.-H., Zhao, C., Xiao, H., and Han, Z. * (2020). Identification of a double-stranded RNA-degrading nuclease influencing both ingestion and injection RNA interference efficiency in the red flour beetle Tribolium castaneum. Insect Biochemistry Molecular Biology 125, 103440.
2019
Zhu, G.-H., Zheng, M.-Y., Sun, J.-B., Khuhro, S.A., Yan, Q., Huang, Y., Syed, Z., and Dong, S.-L. * (2019). CRISPR/Cas9 mediated gene knockout reveals a more important role of PBP1 than PBP2 in the perception of female sex pheromone components in Spodoptera litura. Insect Biochemistry Molecular Biology 115, 103244.
Zhu, G.-H., Jiao, Y., Chereddy, S.C., Noh, M.Y., and Palli, S.R. * (2019). Knockout of juvenile hormone receptor, Methoprene-tolerant, induces black larval phenotype in the yellow fever mosquito, Aedes aegypti. PNAS 116, 21501-21507.
Zhang, Y.-N. #, Zhang, X.-Q. #, Zhu, G.-H., Zheng, M.-Y., Yan, Q., Zhu, X.-Y., Xu, J.-W., Zhang, Y.-Y., He, P., and Sun, L. * (2019). A Δ9 desaturase (SlitDes11) is associated with the biosynthesis of ester sex pheromone components in Spodoptera litura. Pesticide Biochemistry and Physiology 156, 152-159.
Dong, X.T., Liao, H., Zhu, G.-H., Khuhro, S.A., Ye, Z.F., Yan, Q., and Dong, S.L. * (2019). CRISPR/Cas9‐mediated PBP1 and PBP3 mutagenesis induced significant reduction in electrophysiological response to sex pheromones in male Chilo suppressalis. Insect Science 26, 388-399.
2018
Zheng, M., Zhu, G.-H., Chen, Y., Han, Q., Yang, Y., and Dong, S. * (2018). A non-destructive method of genotyping individual insects from the exuviate of final instar larvae, or puparia. Chinese Journal of Applied Entomology 55, 304-309.
Khuhro, S.A., Yan, Q., Liao, H., Zhu, G.-H., Sun, J.-B., and Dong, S.-L. * (2018). Expression profile and functional characterization suggesting the involvement of three chemosensory proteins in perception of host plant volatiles in Chilo suppressalis (Lepidoptera: Pyralidae). Journal of Insect Science 18, 6.
2017
Zhu, G.-H., Peng, Y.-C., Zheng, M.-Y., Zhang, X.-Q., Sun, J.-B., Huang, Y., and Dong, S.-L. * (2017). CRISPR/Cas9 mediated BLOS2 knockout resulting in disappearance of yellow strips and white spots on the larval integument in Spodoptera litura. J Insect Physiol 103, 29-35.
Ye, Z.-F., Liu, X.-L., Han, Q., Liao, H., Dong, X.-T., Zhu, G.-H., and Dong, S.-L. * (2017). Functional characterization of PBP1 gene in Helicoverpa armigera (Lepidoptera: Noctuidae) by using the CRISPR/Cas9 system. Scientific Reports 7, 8470.
Khuhro, S.A., Liao, H., Zhu, G.-H., Li, S.-M., Ye, Z.-F., and Dong, S.-L. * (2017). Tissue distribution and functional characterization of odorant binding proteins in Chilo suppressalis (Lepidoptera: Pyralidae). J Asia-Pac Entomol 20, 1104-1111.
2016
Zhu, G.-H., Xu, J., Cui, Z., Dong, X.-T., Ye, Z.-F., Niu, D.-J., Huang, Y.-P., and Dong, S.-L. * (2016). Functional characterization of SlitPBP3 in Spodoptera litura by CRISPR/Cas9 mediated genome editing. Insect Biochemistry Molecular Biology 75, 1-9.
科研项目
国家自然科学基金青年项目，2022-2024，30万，主持
广东省自然科学基金面上项目，2024-2026， 15万，主持
深圳市基础研究面上项目，2023-2026，30万，主持
中央高校基本业务费中山大学青年拔尖项目，2024-2025，40万，主持
中山大学“百人计划”科研启动项目，2021-2024，60万，主持
