基本介绍

周潇峰
博士  副教授   硕士/博士生导师

Email：zhouxf53@mail.sysu.edu.cn

 

专业方向

  • 课题组研究方向聚焦于柑橘黄龙病与溃疡病的病原细菌生物学，重点关注细菌的生长调节机制，包括但不限于不可培养细菌细胞周期的调控、必需基因的功能解析、细菌在环境胁迫条件下的响应等。实验室长期愿景是破译细菌生长的“密码”，实现对“有害”病原细菌的生长抑制，或对“有益”细菌的生长促进（包括对不可培养细菌的人工培养）。课题组欢迎对科学充满好奇与想象的有志青年学生攻读研究生学位，招生方向为0904-植物保护与095132-资源利用与植物保护。
  • 课题组长期招聘博士后，要求申请人：（1）有以下任意一项研究经历：分子遗传学、生物化学、系统生物学、发育生物学、化学生物学、生物信息学、生物物理或数学；（2）至少发表一篇微生物领域的研究论文；（3）有望在3-5年形成较为系统的有个人特色的研究方向与领域。申请人联系邮箱：zhouxf53@mail.sysu.edu.cn

 

人才项目

省重大人才工程、中山大学”百人计划“

 

教育经历

2011.09-2015.06，佛罗里达大学（University of Florida），微生物与细胞学系（Microbiology & Cell Science），博士

2008.09-2011.06，中国农业大学，植物病理学系，硕士

2004.09-2008.06，吉林大学，植物科学学院，学士

 

工作经历

2024.04至今，中山大学，农业与生物技术学院，副教授

2020.11-2024.03，中山大学，农学院，副教授

2016.09-2020.11，斯坦福大学（Stanford University），发育生物学系（Department of Developmental Biology），博士后

2015.08-2016.08，佛罗里达大学（University of Florida），柑橘研究与教育中心 (Citrus Research and Education Center)，博士后

 

科研成果

Publication (Corresponding author #, First author *)

  1. Liu, C., Zhang, J., Song, M., Wang, X., Lv, W., Ding, X., Zhu, J., Deng, Y., Ge, Y., Wu, J., Handique, U., Duan, S., Shen, Y., Luo, F., Xiao, S., & Zhou, X.# (2025). Propionate serves as a degradable control agent of citrus canker by acidifying cytoplasm and depleting intracellular ATP in Xanthomonas citri. mBio, 16(6), e0064225. https://doi.org/10.1128/mbio.00642-25
  2. Lv, W., Wang, X., Tan, Y., Zhu, J., Ge, Y., Wang, Y., Wu, M., Song, M., Zhang, Y., Shen, Y., Wang, J., Zhang, Y., Li, L., Li, Z., Tan, J., Luo, F., Zheng, L.#, & Zhou, X.# (2025). Essential gene dynamics across distinct growth conditions in Xanthomonas citri. Horticulture Research, 12(9), uhaf160. https://doi.org/10.1093/hr/uhaf160
  3. Guo, M., Wang, A., Zheng, Y., Liu, C., Shao, Q., Deng, Y., Li, L., Wang, Y., Wang, X., Shen, Y., Qian, J., Zhou, X.#, & Fang, Q.# (2025). Cryo-EM structures of a Xanthomonas phage: Insights into viral architecture and implications for the model phage HK97. Structure, S0969-2126(25)00133-9. https://doi.org/10.1016/j.str.2025.03.013
  4. Sun, Y., Utpal, H., Wu, Y., Sun, Q., Feng, Z., Shen, Y., Zhang, R., Zhou, X.#, & Wu, J.# (2024). Comparative genomic and transcriptome analyses of two Pectobacterium brasiliense strains revealed distinct virulence determinants and phenotypic features. Frontiers in Microbiology, 15, 1362283. https://doi.org/10.3389/fmicb.2024.1362283
  5. Wu, Y., Lv, W., Chen, H., Ge, Y., Liu, C., Ding, X., Zou, X., Hu, J., Li, J., Wang, J., Zhang, Y., & Zhou, X.# (2022). Complete Genome Sequence of Xanthomonas citri subsp. citri CQ13, an Alternative Model Strain to Study Citrus Bacterial Canker in China. PhytoFrontiers. https://doi.org/10.1094/PHYTOFR-11-22-0124-A
  6. Zhou, X.*, Eckart, M. R., & Shapiro, L. (2021). A bacterial toxin perturbs intracellular amino acid Balance to induce persistence. mBio, 12(1), e03020-20. https://doi.org/10.1128/mBio.03020-20
  7. Li, J., Xu, S., Mei, Y., Cai, S., Zhou, X., & Wang, J. (2021). First report of Anthracnose on Cinnamomun burmannii Caused by Colletotrichum scovillei in China. Plant Disease. https://doi.org/10.1094/PDIS-07-21-1366-PDN
  8. Lasker, K., von Diezmann, L., Zhou, X., Ahrens, D. G., Mann, T. H., Moerner, W. E., & Shapiro, L. (2020). Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus. Nature Microbiology, 5(3), 418–429. https://doi.org/10.1038/s41564-019-0647-7
  9. Konttinen, O., Carmody, J., Pathuri, S., Anderson, K., Zhou, X., & Reich, N. (2020). Cell cycle regulated DNA methyltransferase: Fluorescent tracking of a DNA strand-separation mechanism and identification of the responsible protein motif. Nucleic Acids Research, 48(20), 11589–11601. https://doi.org/10.1093/nar/gkaa844
  10. Zhou, X.*, Wang, J., Herrmann, J., Moerner, W. E., & Shapiro, L. (2019). Asymmetric division yields progeny cells with distinct modes of regulating cell cycle-dependent chromosome methylation. Proceedings of the National Academy of Sciences of the United States of America, 116(31), 15661–15670. https://doi.org/10.1073/pnas.1906119116
  11. Comerci, C. J., Herrmann, J., Yoon, J., Jabbarpour, F., Zhou, X., Nomellini, J. F., Smit, J., Shapiro, L., Wakatsuki, S., & Moerner, W. E. (2019). Topologically-guided continuous protein crystallization controls bacterial surface layer self-assembly. Nature Communications, 10(1), 2731. https://doi.org/10.1038/s41467-019-10650-x
  12. Zhou, X.*, Teper, D., Andrade, M. O., Zhang, T., Chen, S., Song, W.-Y., & Wang, N. (2018). A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion System in Host. mBio, 9(1), e02146-17. https://doi.org/10.1128/mBio.02146-17
  13. Zhou, X.*, Yan, Q.*, & Wang, N. (2017). Deciphering the regulon of a GntR family regulator via transcriptome and ChIP-exo analyses and its contribution to virulence in Xanthomonas citri. Molecular Plant Pathology, 18(2), 249–262. https://doi.org/10.1111/mpp.12397
  14. Gochez, A. M., Shantharaj, D., Potnis, N., Zhou, X., Minsavage, G. V., White, F. F., Wang, N., Hurlbert, J. C., & Jones, J. B. (2017). Molecular characterization of XopAG effector AvrGf2 from Xanthomonas fuscans ssp. Aurantifolii in grapefruit. Molecular Plant Pathology, 18(3), 405–419. https://doi.org/10.1111/mpp.12408
  15. Li, J., Pang, Z., Trivedi, P., Zhou, X., Ying, X., Jia, H., & Wang, N. (2017). “Candidatus Liberibacter asiaticus” Encodes a Functional Salicylic Acid (SA) Hydroxylase That Degrades SA to Suppress Plant Defenses. Molecular Plant-Microbe Interactions, 30(8), 620–630. https://doi.org/10.1094/MPMI-12-16-0257-R
  16. Zhang, Y., Jalan, N., Zhou, X., Goss, E., Jones, J. B., Setubal, J. C., Deng, X., & Wang, N. (2015). Positive selection is the main driving force for evolution of citrus canker-causing Xanthomonas. The ISME Journal, 9(10), 2128–2138. https://doi.org/10.1038/ismej.2015.15
  17. Zhou, X.*, Hu, X., Li, J., & Wang, N. (2015). A Novel Periplasmic Protein, VrpA, Contributes to Efficient Protein Secretion by the Type III Secretion System in Xanthomonas spp. Molecular Plant-Microbe Interactions, 28(2), 143–153. https://doi.org/10.1094/MPMI-10-14-0309-R

Conference Presentation：

  1. Old Drug, New Path: Leveraging Propionate as a Sustainable Control Agent of Citrus Canker (2024). The 8th Xanthomonas Genomics Conference. Shanghai, China
  2. Phosphorylation swich on Lon controls bacterial type III expression in host (2021). Chinese Society for Plant Pathology, Guizhou, Guiyang, China
  3. Asymmetric division yields progeny cells with distinct modes of cell cycle-dependent chromosome methylation (2019). ASM, San Francisco, CA
  4. Cell-type specific regulation of an essential CcrM DNA methyltransferase (2018). Department Retreat, Monterey, CA
  5. Genome-wide binding sites identification of a GntR transcriptional regulator required for virulence in Xanthomonas citri subsp. citri (2015). American Phytopathological Society, Pasadena, CA
  6. A Sec-dependent periplasmic protein VrpA is required for efficient secretion of type III secretion system and virulence in Xanthomonas citri subsp. citri (2014). American Phytopathological Society, Minneapolis, MN
  7. Dissecting the mechanism of avirulence factor AvrGf1 of Xanthomonas citri in inducing hypersensitive response (HR) on citrus (2013). American Phytopathological Society, Austin, TX

Patent：

  1. 周潇峰; 丁小军; 吕韦玮; 邓云飞; 朱俊安; 孙雨溪; 宋美睿; 王晓莉; 王芸菲; 一种高通量筛选蛋白质互作的体系B2H-seq及使用方法, 2024-11-15, 中国, ZL202410998598.1 (发明专利)
  2. 周潇峰; 刘超颖; 吕韦玮; 丁小军; 朱俊安; 王晓莉; 王芸菲; 丙酸盐在防治柑橘黄单胞杆菌中的应用, 2023-9-15, 中国, ZL202310827159.X (发明专利)
  3. 周潇峰; 王晓兰; 吴漫莹; 吕韦玮; 刘超颖; 丁小军; 黄诚意; 葛一菲; 柑橘溃疡病菌高饱和转座子突变体库及构建方法, 2023-6-20, 中国, ZL202310200163.3 (发明专利)

 

科研项目

  1. 国家自然科学基金面上项目（32472504），柑橘溃疡病菌STPK调控Lon蛋白酶磷酸化及致病力的分子机制，2025-01 至 2028-12，主持
  2. 广东省自然科学基金面上项目（2024A1515012708），丙酸盐抑制柑橘溃疡病菌生长及致病力的分子机制, 2024-01 至 2026-12，主持
  3. 广东省自然科学基金面上项目（2022A1515010905），柑橘溃疡病菌效应子 AvrGf1 抑制寄主免疫反应的分子机制研究, 2022-01 至 2024-12，主持
  4. 华大生命科学研究院开放基金 （BGIRSZ20220003），重要韧皮部杆菌人工可操纵系统的合成生物学设计与构建，2022-01至2024-12，主持

 

Alumni

吕韦玮，21级博士，就职于广东农工商职业技术学院热带农林学院

刘超颖，21级硕士，中山大学生命科学学院攻读博士

丁小军，22级硕士，上海交通大学农业与生物学院攻读博士

王芸菲，21级本科，保送中山大学农业与生物技术学院攻读研究生

王晓莉，21级本科，就职于迈瑞医疗

朱俊安，20级本科，中山大学农业与生物技术学院攻读研究生

陈自黎，20级本科，四川大学生命科学学院攻读研究生

葛一霏，20级本科，全奖攻读新加波南洋理工大学博士

王晓兰，19级本科，全奖攻读香港中文大学（深圳）博士

伍泳琳，19级本科，保送复旦大学攻读研究生

王博，19级本科，保送中国科学技术大学攻读研究生

陈虹宇，19级本科，保送浙江大学攻读研究生

吴漫莹，19级本科，香港大学攻读硕士研究生

黄诚意，19级本科，保送中山大学农业与生物技术学院攻读研究生

孙悦，19级博士（内蒙古大学联培），就职于包头医学院

 

科研服务

中国植物病理学会青年委员会委员，广东省植物病理学会理事，New Plant Protection青年编委，Plant Communication, PLOS Pathogens, PLOS Genetics等期刊审稿人。