基本介绍

博士  教授  博导

 

专业方向

膜蛋白结构与功能

课题组长期招聘博士后，欢迎具有相关研究背景的应聘者将简历发送至lidf9@mail.sysu.edu.cn

 

人才项目

2015年入选国家级青年人才项目，2015年入选“浦江人才A类项目”。

 

教育经历

2002-2006    武汉大学，发育生物学，博士

1995–2002    湖南农业大学，本科、硕士

 

工作经历

2024.11至今，中山大学农业与生物技术学院，教授

2014.11-2024.11，中科院分子细胞科学卓越创新中心，上海生化与细胞所，课题组长，研究员

2006.12-2014.10，爱尔兰利默里克大学；都柏林圣三一学院，博士后

2008.07-2008.08，美国斯克里普斯研究所，短期访问学者

 

科研成果

在磷脂和胆固醇代谢、糖脂修饰蛋白合成与分泌过程中跨膜复合物的组装及工作机制、重要疾病相关的脂质合成、转运、信号转导过程的分子机理等方面获得许多重要发现，在Nat Struct Mol Biol, Nat Commun (×5), EMBO Mol Med, PLoS Pathog 等期刊发表（共同）通讯作者研究论文21篇，书籍3章，综述1篇，在Nature、Nat Commun、Proc Natl Acad Sci USA等学术期刊发表第一或共同第一作者论文12篇。申请国家专利3项。

 

论文、书籍 (*corresponding author; #co-first author) 

  1. Xiong Q. #, Zhu, Z.#, Li, T.#, Li, X., Zhou, Z., Chao, Y., Yang, C., Feng, S., Qu, Q.*, Li, D.* Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling. Nat Struct Mol Biol (2025)
  2. Chao, Y.#, Zhou, Z.#,*, Xia, H.#, Yang, C.#, Li, T., Tang Y., Shu, Y., Ba, Q.*, Hong, J.*, Li, D.*, Qu, Q.* Transport and inhibition mechanism for human TauT-mediated taurine uptake. Cell Res (2025) 
  3. Yue Z. #, Li Y. #, Cai H., Yao H., Li, D., Ni, A.*, Li, T.* Structure-based design of covalent nanobody binders for a thermostable green fluorescence protein. Acta Biochim Biophys Sin (2024)
  4. Chen, Y.#, Zha, J.#, Xu, S., Shao, J., Liu, X., Li, D.*, Zhang, X.* Structure-Based Optimization of One Neutralizing Antibody against SARS-CoV-2 Variants Bearing the L452R Mutation. Viruses 16:566 (2024)
  5. Li, D. Structure and Function of the Glycosylphosphatidylinositol Transamidase, a Transmembrane Complex Catalysing GPI Anchoring of Proteins. In: Harris, JR., Marles-Wright J. (eds) Macromolecular Protein Complexes V. Springer, Cham Ch. 16 pp 425-458 (2024) (book chapter)
  6. Hong, J.#, Li, T.#, Chao, Y.#, Xu, Y., Zhu, Z., Zhou, Z., Gu, W., Qu, Q.*, Li, D.* Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis. Nat Commun 15:8 (2024)
  7. Li, T., Cai H., Lai, Y., Yao, H., Li, D.* A simple and effective method to remove pigments from heterologous secretory proteins expressed in Pichia pastoris. Adv Biotechnol 2: 5 (2024)
  8. Li, T.#, Zhou, B.#, Dong, H., Lavillette D.*, Li, D.* A human antibody derived from original SARS-CoV-2 infection effectively neutralizes omicron. Adv Biotechnol 2: 2 (2024)
  9. Wang, Y.#, Zhang, P.#, Chao, Y.#, Zhu, Z.#, Yang, C.#, Zhou, Z.#, Li, Y., Long, Y., Liu, Y., Li, D., Wang, S.*, Qu, Q.* Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines. Cell Res 34:47-57 (2024)
  10. Yu, S.#, Zheng, X. #, Zhou, Y. #, Gao, Y., Zhou, B., Zhao, Y., Li, T., Li, Y., Mou, J., Cui, X., Yang, Y., Li, D., Chen, M.*, Lavillette, D.*, Meng, G.* Antibody-mediated spike activation promotes cell-cell transmission of SARS-CoV-2. PLoS Pathog ppat.1011789 (2023)
  11. Xu, Y.#, Li, T.#, Zhou, Z.#, Hong, J., Chao, Y., Zhu, Z., Zhang, Y., Qu, Q.*, Li, D.* Structures of Liganded Glycosylphosphatidylinositol Transamidase Illuminate GPI-AP Biogenesis. Nat Commun 14:5520 (2023)
  12. Li, Y.#, Peng, J. #,*, Xia, Y., Pan, C., Li, Y., Gu, W., Wang, J., Wang, C., Wang, Y., Song, J., Zhou, X., Ma, L., Jiang, Y., Liu, B., Feng, Q., Wang, W., Jiao, S., An, L., Li, D., Zhou, Z.*, Zhao, Y.* Sufu limits sepsis-induced lung inflammation via regulating phase separation of TRAF6. Theranostics 13:3761-3780 (2023)
  13. Wang X.#, He, X.#, Jiang S.#, Fu, Z.#, Jiang S., Zhao, X., Zhao, C., Li, Y., Li, D., Zhang, W., Ai, J.*, Zhang, Y.*, Xu, C.*, Wang, P.* Limited enhancement of antibody and B-cell responses to prototype booster vaccination following SARS-CoV-2 Delta breakthrough infection. J Med Virol 2:e28540 (2023)
  14. Lu, M.#, Zha, J.#, Zhou, B.#, Cao, L.#, Jiang, C., Zhu, Y., Li, T., Lu, L., Zhang, J., Yang, H., Feng, J., Gu, Z., Tang, H., Jiang, L., Li, D.*, Lavillette, D.*, Zhang, X.* A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy. PLoS Pathog 19: e1011085 (2023)
  15. Yao, H., Cai, H., Li, D.* Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Proteins. Methods Mol Biol 2564:299-315 (2023) (book chapter)
  16. Yang, Z.#, Xia, J.#, Hong, J.#, Zhang, C., Wei, H., Ying, W., Sun, C., Sun, L., Mao, Y., Gao, Y., Tan, S., Friml J., Li, D., Liu, X.*, Sun, L.* Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature 609:611-615 (2022)
  17. Xu, Y.#, Jia, G.#, Li, T.#, Zhou, Z.#, Luo, Y., Cao, Y., Bao, J., Su, Z.*, Qu, Q.* & Li, D.* Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins. Nat Commun 13:2617 (2022)
  18. Li, T.#, Zhou, B.#, Li, Y., Huang, S., Luo, Z., Zhou, Y., Lai, Y., Gautam, A., Bourgeau, S., Wang, S., Bao, J., Tan, J., Lavillette, D.*, Li, D.* Isolation, characterization, and structure-based engineering of a neutralizing nanobody against SARS-CoV-2. Inter J Biol Macromol 209:1379-1388 (2022)
  19. Li, T.#, Zhou, B.#, Luo, Z.#, Lai, Y., Huang, S., Zhou, Y., Li, Y., Gautam, A., Bourgeau, S., Wang, S., Bao, J., Tan, J., Lavillette, D.*, Li, D.* Structural characterization of a neutralizing nanobody with broad activity against SARS-CoV-2 variants. Front Microbiol 13:875840 (2022)
  20. Luo, Z., Gu, W., Wang, Y., Tang, Y., Li, D.* Selenourea for Experimental Phasing of Membrane Protein Crystals Grown in Lipid Cubic Phase. Crystals 12:976 (2022)
  21. Yang, B., Yao, H., Li, D., Liu, Z.* The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface. Curr Res Struct Biol 3:312-323 (2021)
  22. Li, T.#, Cai, H.#, Zhao, Y.#, Li, Y.#, Lai, Y.#, Yao, H.#, Liu, DL.#, Sun, Z.#, van Vlissingen, MF., Kuiken, T., GeurtsvanKessel, CH., Zhang, N., Zhou, B., Lu, L., Cong, Y., Qin, W., Mondal, M., Duan, B., Xu, S., Richard AS., Raoul, H., Chen, JF., Xu, C., Wu, L., Zhou, H., Huang, Z., Zhang, X., Li, J., Wang, Y., Bi, Y., Rockx., Chen, J.*, Meng, FL.*, Lavillette, D.*, Li, D.* Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody. EMBO Mol Med, 13:e14544 (2021)
  23. Luo, Y.#, Wan, G.#, Zhou, X.#, Wang, Q., Zhang, Y., Bao, J., Cong, Y., Zhao, Y.*, Li, D.* Architecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release. Front Mol Biosci, 8:701826 (2021)
  24. Li, T.#, Cai, H.#, Yao, H.#, Zhou, B.#, Zhang, N.#, van Vlissingen, MF., Kuiken, T., Han, W., GeurtsvanKessel, CH., Gong, Y., Zhao, Y., Shen, Q., Qin, W., Tian, X., Peng, C., Lai, Y., Wang, Y., Hutter, CAJ., Kuo, S-M., Bao, J., Liu, C., Wang, Y., Richard, AS., Raoul, H., Lan, J., Seeger, MA., Cong, Y., Rockx., Wong, G.*, Bi, Y.*, Lavillette, D.*, Li, D*. A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection. Nat Commun, 12:4635 (2021)
  25. Luo, Y.#, Wan, G.#, Zhang, X.#, Zhou, X.#, Wang, Q., Fan, J., Cai, H., Ma, L., Wu, H., Qu, Q.*, Cong, Y.*, Zhao, Y.*, Li, D.* Cryo-EM study of Patched in lipid nanodisc suggests a structural basis for its clustering in caveolae. Structure 29: 1286-1294 (2021)
  26. Yao, H.#, Cai, H.#, Li, T.#, Zhou, B.#, Qin, W., Lavillette, D.*, Li, D.* A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2. PLoS Pathog 17:e1009328 (2021)
  27. Zhang L.#, Yao D.#, Xia, Y.#, Zhou, F., Zhang, Q., Wang, Q., Qin, A., Zhao, J., Li, D., Li, Y.*, Zhou, L.*, Cao, Y.* The structural basis for glycerol permeation by human AQP7. Sci Bull 66:1550-1558 (2021)
  28. Cai, H.#, Yao, H.#, Li, T.#, Hutter, C.A.J., Li, Y., Tang, Y., Seeger, M.A., Li, D.* An improved fluorescent tag and its nanobodies for membrane protein expression, stability assay, and purification. Commun Biol 3:753 (2020)
  29. Yuan, Y. Cao, C. Wen, M. Li, M. Dong, Y. We, L. Wu, J. Cui, T. Li, D.* Chou, J.J.* Ouyang B.* Structural Characterization of the N-Terminal Domain of the Dictyostelium discoideum Mitochondrial Calcium Uniporter. ACS Omega 10.1021/acsomega.9b04045 (2020)
  30. Li, D.,* Caffrey, M.* Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase. J Mol Biol 432:5104-5123 (2020) (review)
  31. Yao, H#., Cai, H#., Li, D*. Thermostabilization of membrane proteins by consensus mutation: a case study for a fungal D8-7 sterol isomerase. J Mol Biol 432:5162-5183 (2020)
  32. Cai, H#. Yao, H#. Li, T. Tang, Y.,  Li, D*. High-level heterologous expression of the human transmembrane sterol Δ8,Δ7-isomerase in Pichia pastoris. Protein Expr Purif 164:105463 (2019)
  33. Tang, Y. Li, D*. Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase. Assay Drug Dev Techn 17, 267-274 (2019)
  34. Wang, D. Hu, X. Liu, C. Jia, Y. Bai, Y. Cai, C. Qang, Q. Bai, L. Yang, R. Lin, C. Liu, Y. Li, S. Qiao, F. Yao, L. Chen, L. Ge, G. Jiang, H. Li, D. Li, L. Chen, J. Shao, ZM. Zeng, YA. Protein C receptor is a therapeutic stem cell target in a distinct group of breast cancers. Cell Res 29:832-845 (2019)
  35. Al-Sahouri, Z., Lee, M-Y., Li, D., Liu, W., Caffrey, M. The Lipid Cubic Phase as a Medium for the Growth of Membrane Protein Microcrystals: A Revolution in Structural Biology. In: Boutet S., Fromme P., Hunter M. (eds) X-ray Free Electron Lasers. Springer, Cham Ch. 4 pp 87-108 (2018) (book chapter)
  36. Li, Z#., Tang, Y#., Li, D*. In Meso Crystallization of the Integral Membrane Glycerol 3-Phosphate Acyltransferase with Substrates. Cryst Growth Des 18,2243-2258, (2018)
  37. Tang Y., Xia H., Li D*. (2018) Membrane Phospholipid Biosynthesis in Bacteria. In: Cao Y. (eds) Advances in Membrane Proteins. Springer, Singapore Ch. 4 pp 77-119 (2018) (book chapter)
  38. Li, Z#., Tang, Y#., Wu, Y., Zhao S., Bao, J., Luo, Y., Li, D*. Structural insights into the committed step of bacterial phospholipid biosynthesis. Nat Commun 8, 1691(2017). 
  39. Zha, J. & Li, D*. Lipid cubic phase for membrane protein X-ray crystallography. In: Wang H., Li G. (eds) Membrane Biophysics. Springer, Singapore Ch. 7, pp 175-220 (2018) (book chapter)
  40. Luo, Q., Yang, X., Yu, S., Shi, H., Wang, K., Xiao, L., Zhu, G., Sun, C., Li, T., Li, D., Zhang, X., Zhou, M. & Huang, Y*. Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG. Nat Struct Mol Biol24, 469-474, (2017).
  41. Bao, Z., Qi, X., Hong, S., Xu, K., He, F., Zhang, M., Chen, J., Chao, D., Zhao, W., Li, D., Wang, J. & Zhang, P*. Structure and mechanism of a group-I cobalt energy coupling factor transporter. Cell Res 27, 675-687, (2017).
  42. Zhou, X. E., Gao, X., Barty, A., Kang, Y., He, Y., Liu, W., Ishchenko, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., de Waal, P. W., Suino-Powell, K. M., Boutet, S., Williams, G. J., Wang, M., Li, D., Caffrey, M., Chapman, H. N., Spence, J. C. H., Fromme, P., Weierstall, U., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E*. X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex. Sci Data 3, 160021, (2016).
  43. Prabhu, A., Luu, W., Li, D., Sharpe, L. & J. Brown, A*. DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Prog Lipid Res 64, 138-151, (2016). (review)
  44. Olieric, V., Weinert, T., Finke, A. D., Anders, C., Li, D., Olieric, N., Borca, C. N., Steinmetz, M. O., Caffrey, M., Jinek, M. & Wang*, M. Data-collection strategy for challenging native SAD phasing. Acta Crystallogr D 72, 421-429, (2016).
  45. Howe, V., Sharpe, L. J., Alexopoulos, S. J., Kunze, S. V., Chua, N. K., Li, D. & Brown, A. J*. Cholesterol homeostasis: How do cells sense sterol excess? Chem Phys Lipids 199, 170-178, (2016). (review)
  46. Li, D., Stansfeld, P. J., Sansom, M. S. P., Keogh, A., Vogeley, L., Howe, N., Lyons, J. A., Aragao, D., Fromme, P., Fromme, R., Basu, S., Grotjohann, I., Kupitz, C., Rendek, K., Weierstall, U., Zatsepin, N. A., Cherezov, V., Liu, W., Bandaru, S., English, N. J., Gati, C., Barty, A., Yefanov, O., Chapman, H. N., Diederichs, K., Messerschmidt, M., Boutet, S., Williams, G. J., Marvin Seibert, M. & Caffrey, M*. Ternary structure reveals mechanism of a membrane diacylglycerol kinase. Nat Commun 6, 10140, (2015).
  47. Li, D., Pye, V. E. & Caffrey, M*. Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method. Acta Crystallogr D 71, 104-122, (2015).
  48. Kang, Y., Zhou, X. E., Gao, X., He, Y., Liu, W., Ishchenko, A., Barty, A., White, T. A., Yefanov, O., Han, G. W., Xu, Q., de Waal, P. W., Ke, J., Eileen Tan, M. H., Zhang, C., Moeller, A., West, G. M., Pascal, B., Van Eps, N., Caro, L. N., Vishnivetskiy, S. A., Lee, R. J., Suino-Powell, K. M., Gu, X., Pal, K., Ma, J., Zhi, X., Boutet, S., Williams, G. J., Messerschmidt, M., Gati, C., Zatsepin, N. A., Wang, D., James, D., Basu, S., Roy-Chowdhury, S., Conrad, C., Coe, J., Liu, H., Lisova, S., Kupitz, C., Grotjohann, I., Fromme, R., Jiang, Y., Tan, M., Yang, H., Li, J., Wang, M., Zheng, Z., Li, D., Howe, N., Zhao, Y., Standfuss, J., Diederichs, K., Dong, Y., Potter, C. S., Carragher, B., Caffrey, M., Jiang, H., Chapman, H. N., Spence, J. C. H., Fromme, P., Weierstall, U., Ernst, O. P., Katritch, V., Gurevich, V. V., Griffin, P. R., Hubbell, W. L., Stevens, R. C., Cherezov, V., Melcher, K. & Xu, H. E*. Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 523, 561-567, (2015).
  49. Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Li, D., Howe, N., Schnapp, G., Pautsch, A., Bargsten, K., Prota, A. E., Surana, P., Kottur, J., Nair, D. T., Basilico, F., Cecatiello, V., Pasqualato, S., Boland, A., Weichenrieder, O., Wang, B. C., Steinmetz, M. O., Caffrey, M. & Wang, M*. Fast native-SAD phasing for routine macromolecular structure determination. Nat Methods 12, 131-133, (2014).
  50. Weierstall, U*., James, D., Wang, C., White, T. A., Wang, D., Liu, W., Spence, J. C., Bruce Doak, R., Nelson, G., Fromme, P., Fromme, R., Grotjohann, I., Kupitz, C., Zatsepin, N. A., Liu, H., Basu, S., Wacker, D., Han, G. W., Katritch, V., Boutet, S., Messerschmidt, M., Williams, G. J., Koglin, J. E., Marvin Seibert, M., Klinker, M., Gati, C., Shoeman, R. L., Barty, A., Chapman, H. N., Kirian, R. A., Beyerlein, K. R., Stevens, R. C., Li, D., Shah, S. T., Howe, N., Caffrey, M. & Cherezov, V*. Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat Commun 5, 3309, (2014).
  51. Tan, J#., Rouse, S. L#., Li, D#., Pye, V. E., Vogeley, L., Brinth, A. R., El Arnaout, T., Whitney, J. C., Howell, P. L., Sansom, M. S. & Caffrey, M*. A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa. Acta Crystallogr D 70, 2054-2068, (2014).
  52. Nji, E., Li, D., Doyle, D. A. & Caffrey, M*. Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa. Acta Crystallogr F 70, 1362-1367, (2014).
  53. Lyons, J. A#., Parker, J. L#., Solcan, N., Brinth, A., Li, D., Shah, S. T., Caffrey, M*. & Newstead, S*. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep 15, 886-893, (2014).
  54. Li, D., Howe, N., Dukkipati, A., Shah, S. T., Bax, B. D., Edge, C., Bridges, A., Hardwicke, P., Singh, O. M., Giblin, G., Pautsch, A., Pfau, R., Schnapp, G., Wang, M., Olieric, V. & Caffrey, M*. Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy. Cryst Growth Des 14, 2034-2047, (2014).
  55. Li, D. & Caffrey, M*. Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic. Sci Rep 4, 5806, (2014).
  56. Caffrey, M*., Li, D., Howe, N. & Shah, S. T. 'Hit and run' serial femtosecond crystallography of a membrane kinase in the lipid cubic phase. Philos Trans R Soc Lond B Biol Sci 369, 20130621, (2014).
  57. Caffrey, M*., Eifert, R., Li, D. & Howe, N. The lipid cubic phase or method for crystallizing proteins. Bushings for better manual dispensing. J Appl Crystallogr 47, 1804-1806, (2014).
  58. Boland, C#., Li, D#., Shah, S. T., Haberstock, S., Dotsch, V., Bernhard, F. & Caffrey, M*. Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination. Cell Mol Life Sci 71, 4895-4910, (2014).
  59. Liu, W., Wacker, D., Gati, C., Han, G. W., James, D., Wang, D., Nelson, G., Weierstall, U., Katritch, V., Barty, A., Zatsepin, N. A., Li, D., Messerschmidt, M., Boutet, S., Williams, G. J., Koglin, J. E., Seibert, M. M., Wang, C., Shah, S. T., Basu, S., Fromme, R., Kupitz, C., Rendek, K. N., Grotjohann, I., Fromme, P., Kirian, R. A., Beyerlein, K. R., White, T. A., Chapman, H. N., Caffrey, M., Spence, J. C., Stevens, R. C. & Cherezov, V*. Serial femtosecond crystallography of G protein-coupled receptors. Science 342, 1521-1524, (2013).
  60. Li, D., Shah, S. T. A. & Caffrey, M*. Host Lipid and Temperature as Important Screening Variables for Crystallizing Integral Membrane Proteins in Lipidic Mesophases. Trials with Diacylglycerol Kinase. Cryst Growth Des 13, 2846-2857, (2013).
  61. Li, D., Lyons, J. A., Pye, V. E., Vogeley, L., Aragao, D., Kenyon, C. P., Shah, S. T., Doherty, C., Aherne, M. & Caffrey, M*. Crystal structure of the integral membrane diacylglycerol kinase. Nature 497, 521-524, (2013).
  62. Hopper, J. T., Yu, Y. T., Li, D., Raymond, A., Bostock, M., Liko, I., Mikhailov, V., Laganowsky, A., Benesch, J. L., Caffrey, M., Nietlispach, D. & Robinson, C. V*. Detergent-free mass spectrometry of membrane protein complexes. Nat Methods 10, 1206-1208, (2013).
  63. Caffrey M*, Li, D. Dukkipati, A. Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes. Biochemistry51,6266-6288 (2012)
  64. Li, D., Boland, C., Walsh, K. & Caffrey, M*. Use of a robot for high-throughput crystallization of membrane proteins in lipidic mesophases. J Vis Exp e4000, (2012).
  65. Li, D., Boland, C., Aragao, D., Walsh, K. & Caffrey, M*. Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography. J Vis Exp e4001, (2012).
  66. Nederlof, I., Hosseini, R., Georgieva, D., Luo, J., Li, D. & Abrahams, J. P*. A Straightforward and Robust Method for Introducing Human Hair as a Nucleant into High Throughput Crystallization Trials. Cryst Growth Des 11, 1170-1176, (2011).
  67. Li, D., Lee, J. & Caffrey, M*. Crystallizing Membrane Proteins in Lipidic Mesophases. A Host Lipid Screen. Cryst Growth Des 11, 530-537, (2011).
  68. Li, D. & Caffrey, M*. Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes. Proc Natl Acad Sci U S A 108, 8639-8644, (2011).

 

主要科研项目

主要承担自然科学基金原创探索、国际合作、面上项目、培育项目，中科院前沿科学重点研究项目，参与中科院先导B类专项、中科院基础设施开放重点项目等10余项科研课题。

 

 

社会兼职

任中国生物物理学会分子生物物理分会理事及国际生物大分子结晶组织（IOBCr）理事