基本介绍

王东皓

博士 副教授 硕导（生物学（学术学位） & 资源利用与植物保护（专业学位））

 

专业方向

海洋食品，脂质组学，质谱技术，食品营养学研究

 

人才项目

百人计划     

 

教育经历

2013.08-2017.08，美国康奈尔大学（Cornell University），食品科学与工程，博士学位

2012.08-2013.08，美国康奈尔大学（Cornell University），食品科学与工程，硕士学位

2008.09-2012.05，暨南大学，1) 食品质量与安全2) 商务英语（获英语专业8级证书），双学士学位

 

工作经历

2024.04至今，中山大学，农业与生物技术学院，副教授

2022.06-2024.03，中山大学，农学院，副教授

2017.08-2021.07，美国德州大学奥斯汀分校 (University of Texas at Austin) 戴尔医学院，博士后

 

科研成果

发表文章

  1. Wang Z; Yang T; Yang H; Rahman MS; Brenna JT; Wang, DH*; Polymethylene-Interrupted, Omega-3 and Branched-Chain Fatty Acids and Stable 13C Values of Wild Gulf of Mexico Oysters (Crassostrea virginica) from the Texas Coast, Journal of Agricultural and Food Chemistry, 2025, 73 (16), 9846-9853.
  2. Qi L#; Li X#; Ren Y; Yang T; Guan Y; Wang DH*; Wang Z*, A Facile Workflow for Sebum Fatty Acids and Squalene Identification via Advanced Lipidomic Methodologies. Analytical Chemistry 2025, 97 (18), 9664-9674.
  3. Yang T; Qi L; Yang H; Xia Y; Wang Z; Wang DH*, Highly Sensitive Chemical Ionization Tandem Mass Spectrometry Method for the Identification of Unsaturated Fatty Acids Derivatized by Dimethyl Disulfide. Journal of the American Society for Mass Spectrometry 2025, 36 (5), 1158-1166.
  4. Yang H; Yang T; Qi L; Zhang Y; Xia Y; Wang Z*; Wang DH*, Unusual polyunsaturated fatty acids in edible marine worms identified by covalent adduct chemical ionization mass spectrometry. Food Chemistry 2025, 463, 141287.
  5. Dai C; Qi L; Yang T; Wang Z*; Wang DH*, Mass spectrometry differentiation of sciadonic acid isomers and estimate of long-chain polyunsaturated fatty acid intake from fresh and processed duck eggs. Journal of Food Composition and Analysis 2025, 140, 107253.
  6. Wang DH; Qi L; Yang T; Dai C; Brenna JT*; Wang Z*, Omega-3 Long-Chain Polyunsaturated Fatty Acids in Nonseafood and Estimated Intake in the USA: Quantitative Analysis by Covalent Adduct Chemical Ionization Mass Spectrometry. Journal of Agricultural and Food Chemistry 2024, 72 (27), 15311-15320.
  7. Wang Z; Garza S; Li X; Rahman MS; Brenna JT*; Wang DH*, Paterno-Buchi Reaction Mass Spectrometry Enables Positional Assignment of Polymethylene-Interrupted Double Bonds in Food-Derived Lipids. Journal of Agricultural and Food Chemistry 2024, 72 (6), 3180-3188.
  8. Wang DH; Qi L; Yang T; Ren Y; Wang Z*, Skin derived branched-chain fatty acids in fetal horse gut. European Journal of Lipid Science & Technology 2024, 126 (10), 2400060.
  9. Wang Z; Yang T; Brenna JT*; Wang DH*, Fatty acid isomerism: analysis and selected biological functions. Food & Function 2024, 15 (3), 1071-1088 [Review]
  10. Wang DH, Vidovic D, et al.: Quantitative High Field NMR and Mass Spectrometry-Based Fatty Acid Sequencing Reveals Internal Structure in Ru-catalyzed Deuteration of Docosahexaenoic Acid. Analytical Chemistry 2022 [中科院大类一区Top;IF:6.986]
  11. Wang DH, Park HG, Wang Z, Lacombe RS, Shmanai VV, Bekish AV, Schmidt K, Shchepinov MS, Brenna JT: Toward Quantitative Sequencing of Deuteration of Unsaturated Hydrocarbon Chains in Fatty Acids. Analytical Chemistry 2021, 93(23):8238−8247 [中科院大类一区Top;IF:6.986]
  12. Wang DH, Wang Z, Li X, Martinez S, James G, Rahman MS, Brenna, JT: Unusual Polymethylene-Interrupted, Δ5 Monounsaturated and Omega-3 Fatty Acids in Sea Urchin (Arbacia punctulata) from the Gulf of Mexico identified by Solvent Mediated Covalent Adduct Chemical Ionization Mass Spectrometry. Food Chemistry 2022, 371:131131 [中科院大类一区Top;IF:7.514]
  13. Wang DH, Wang Z, Cortright JR, Le KP, Liu L, Kothapalli KSD, Brenna JT: Identification of polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFA) by solvent-mediated covalent adduct chemical ionization triple quadrupole tandem mass spectrometry. Analytical Chemistry 2020, 92(12):8209–8217         [中科院大类一区Top;IF:6.986]
  14. Wang DH, Wang Z, Chen R, Kothapalli KS, Brenna JT. Very Long-Chain Branched-Chain Fatty Acids in Chia Seeds: Implications for Human Use. Journal of Agricultural and Food Chemistry 2020, 68(47):13871-8 [中科院大类一区Top;IF:5.279]
  15. Wang DH, Wang Z, Chen R, Brenna JT: Characterization and semiquantitative analysis of novel ultratrace C10–24 monounsaturated fatty acid in bovine milkfat by solvent-mediated covalent adduct chemical ionization (CACI) MS/MS. Journal of Agricultural and Food Chemistry 2020, 68(28):7482-7489 [中科院大类一区Top;IF:5.279]
  16. Wang DH, Wang Z, Brenna JT: Gas chromatography chemical ionization (CI) mass spectrometry (MS) and MS/MS for identification and straightforward quantification of branched chain fatty acids in foods. Journal of Agricultural and Food Chemistry 2020, 68(17):4973-4980 [中科院大类一区Top;IF:5.279]
  17. Wang DH, Wang Z, Le KP, Cortright JR, Park HG, Tobias HJ, Brenna JT: Potentially High Value Conjugated Linolenic Acids (CLnA) in Melon Seed Waste. Journal of Agricultural and Food Chemistry 2019, 67(37):10306-10312 [中科院大类一区Top;IF:5.279]
  18. Wang DH, Yang Y, Wang Z, Lawrence P, Worobo RW, Brenna JT: High levels of branched chain fatty acids in natto and other Asian fermented foods. Food Chemistry 2019, 286:428-433 [中科院大类一区Top;IF:7.514]
  19. Wang DH, Ran-Ressler R, St Leger J, Nilson E, Palmer L, Collins R, Brenna JT: Sea Lions Develop Human-like Vernix Caseosa Delivering Branched Fats and Squalene to the GI Tract. Scientific Reports 2018, 8(1):7478 [中科院大类三区Top;IF:4.379]
  20. Wang DH, Jackson JR, Twining C, Rudstam LG, Zollweg-Horan E, Kraft C, Lawrence P, Kothapalli K, Wang Z, Brenna JT: Saturated Branched Chain, Normal Odd-Carbon-Numbered, and n-3 (Omega-3) Polyunsaturated Fatty Acids in Freshwater Fish in the Northeastern United States. Journal of Agricultural and Food Chemistry 2016, 64(40):7512-7519 [中科院大类一区Top;IF:5.279]
  21. Wang DH, Wang Z, Martinez S, Tobias HJ, Brenna JT: Fatty acid sentinels as covalently bound randomization standards for triacylglycerol (TAG) quantitative analysis. Rapid Commun Mass Spectrom 2020, 34(20):8891 [中科院大类三区;IF:2.419]
  22. Wang Z, Park HG, Wang DH, Kitano R, Kothapalli KSD, Brenna JT: Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids. Biochim Biophys Acta Mol Cell Biol Lipids 2020, 1865(3):158572
  23. Wang Z, Wang DH, Park HG, Tobias HJ, Kothapalli KSD, Brenna JT: Structural Identification of Monounsaturated Branched Chain Fatty Acid Methyl Esters by Combination of Electron Ionization and Covalent Adduct Chemical Ionization Tandem Mass Spectrometry. Analytical Chemistry 2019, 91(23):15147-15154
  24. Wang Z, Wang DH, Goykhman Y, Yan Y, Lawrence P, Kothapalli KSD, Brenna JT: The elongation of very long-chain fatty acid 6 gene product catalyses elongation of n-13 : 0 and n-15 : 0 odd-chain SFA in human cells. Br J Nutr 2019:1-8
  25. Wang Z, Wang DH, Park HG, Yan Y, Goykhman Y, Lawrence P, Kothapalli KSD, Brenna JT: Identification of genes mediating branched chain fatty acid elongation. FEBS Lett 2019, 593(14):1807-1817
  26. Yan Y, Wang Z, Wang D, Lawrence P, Wang X, Kothapalli KSD, Greenwald J, Liu R, Park HG, Brenna JT: BCFA-enriched vernix-monoacylglycerol reduces LPS-induced inflammatory markers in human enterocytes in vitro. Pediatr Res 2018, 83(4):874-879
  27. Sun W, Luo Y, Wang DH, Kothapalli KSD, Brenna JT: Branched chain fatty acid composition of yak milk and manure during full-lactation and half-lactation. Prostaglandins Leukot Essent Fatty Acids 2019, 150:16-20
  28. Jain P, Nattakom M, Holowka D, Wang DH, Thomas Brenna J, Ku AT, Nguyen H, Ibrahim SF, Tumbar T: Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity. Stem Cells 2018, 36(10):1603-1616
  29. Wijendran V, Brenna JT, Wang DH, Zhu W, Meng D, Ganguli K, Kothapalli KS, Requena P, Innis S, Walker WA: Long-chain polyunsaturated fatty acids attenuate the IL-1beta-induced proinflammatory response in human fetal intestinal epithelial cells. Pediatr Res 2015, 78(6):626-633
  30. Di Rienzi SC, Johnson EL, Waters JL, Kennedy EA, Jacobson J, Lawrence P, Wang DH, Worgall TS, Brenna JT, and Ley RE: The microbiome affects liver sphingolipids and plasma fatty acids in a murine model of the Western diet based on soybean oil. J Nutr Biochem 2021, 97:108808
  31. Ran-Ressler RR, Bae S, Lawrence P, Wang DH, Brenna JT: Branched-chain fatty acid content of foods and estimated intake in the USA. Br J Nutr 2014, 112(4):565-572
  32. Wang DH & Brenna JT, in Holčapek, Michal (ed.), Mass Spectrometry for Lipidomics: Methods and Applications, 2022-Wiley著作（Wiley出版社邀稿书籍篇章）

科研项目：

广东省自然科学基金面上项目，2025-2027，主持
中山大学“百人计划”科研启动项目，2022-2025，主持

 

社会兼职

美国油脂化学家协会（American Oil Chemists’ Society）会员

美国质谱学会（American Society for Mass Spectrometry）会员

国际脂肪酸与脂质研究学会（International Society for the Study of Fatty Acids and Lipids）会员

Food Chemistry, Chemical Science, Analytical Chemistry, Journal of Agricultural and Food Chemistry, Plos One, British Journal of Nutrition等同行审稿人